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Skip navigation   a-z calendar directory maps contact us home about research interests future students faculty current students alumni give   search faculty home faculty directory research descriptions search program affiliations program directors seeking students apply meetings standing committees by-laws core tenets history information technology quick links   dr. Alexander j. cheap viagra F. get viagra prescription online Lazar regular member ut m. D. generic viagra without prescription Anderson cancer center pathology research interests: soft tissue sarcoma tumor biology and tumorigenesis cutaneous adnexal tumors and stem cells melanoma studies in our group currently address soft tissue sarcoma biology with particular interest in the early genetic changes associated with tumorigenesis. Soft tissue sarcomas are a large family of malignancies showing various patterns of mesenchymal differentiation. buy viagra jelly uk Precursor (in situ) lesions are not described in soft tissue sarcomas and little is known of the cell of origin. A subset of sarcomas are associated with unique chromosomal translocations that produce a novel fusion genes that appear to drive their biology (e. G. generic viagra canada , ewing sarcoma, synovial sarcoma, clear cell sarcoma, dermatofibrosarcoma protuberans, & alveolar soft part sarcoma) while others are associated with an initiating single activating point mutation in a proto-oncogene (e. G. viagra pills , desmoid fibromatosis and gastrointestinal stromal tumor). We have examined the prevalence and type of mutations present in various sarcomas and correlated these with tumor biology and clinical outcome. viagra online purchase canada One model system is desmoid fibromatosis where we are characterizing beta-catenin (encoded by ctnnb1) exon 3 mutations and have discovered a high incidence of such mutations. These mutations cause beta-catenin to accumulate in the nucleus and act as a constitutive transcription factor in concert with other nuclear proteins. Unlike epithelial tumors with beta-catenin mutations, we see only three specific mutations. http://classicmotocrossimages.com/mbs-viagra-for-sale-generic-im/ This finding indicates that the specific mutation present may have biologic significance. cheap viagra online We are using human tumor samples and cell lines derived from human tumors to understand the role and significance of the beta-catenin pathway in desmoid tumors. We are attempting to model desmoid tumors by expressing mutated beta-catenin in fibroblasts and primitive mesenchymal cells.   this study has led to the deve. Date Created: Wed Apr 6 09:18:39 2011